Absence of Epstein-Barr virus carrying cells in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis.

نویسندگان

  • P Brousset
  • M Caulier
  • A Cantagrel
  • C Dromer
  • B Mazières
  • G Delsol
چکیده

OBJECTIVES To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. CONCLUSIONS Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study.

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عنوان ژورنال:
  • Annals of the rheumatic diseases

دوره 52 8  شماره 

صفحات  -

تاریخ انتشار 1993